Multiple dose pharmacokinetics of quetiapine and some of its metabolites in Chinese suffering from schizophrenia

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: quetiapine pharmacokinetics metabolism schizophrenia Chinese
• 年，卷（期）: 2004,（3）
• 页码范围: 390-394
• 页数: 5页
• 分类号: R96
• 语种: 英文

摘要

AIM: To study the multiple dose pharmacokinetics of quetiapine and its sulfoxide-, 7-hydroxy-, 7-hydroxy-Ndealkyl-metabolites in Chinese suffering from schizophrenia. METHODS: Twenty-one patients (11 females and 10males) were given quetiapine twice daily to control the symptoms. After the dose reached 200 mg twice daily,blood were sampled to study the pharmacokinetics. The plasma concentrations of quetiapine and its metabolites were assayed by HPLC-MS. RESULTS: The main pharmacokinetic parameters of quetiapine, 7-hydroxy-N-dealkylquetiapine, quetiapine sulfoxide, and 7-hydroxy-quetiapine were as follows: tmax were 2.0 (0.3-5.0), 4.0 (1.5-6.0),3.0 (0.5-5.0), and 3.0 (0.5-5.0) h respectively; t1/2 were (7±3), (9.4±2.7), (7±3), and (8±5) h, respectively; CSSmaxwere (678±325), (19±5), (451±216), and (58±22) μg/L, respectively; CSSmin were (51±68), (3.3±1.6), (35±36), and (5±4) μg/L, respectively; CSSav were (295±144), (13±4), (209±71), and (28±9) μg/L, respectively; AUCSS0-12 were (0.103±0.028) h-1, respectively; CL/F and V/F of quetiapine were (67±25) L.h-1 and (672±394) L, respectively.The plasma concentrations for the four compounds reached a steady state within 48 h at the dose of 200 mg initiation. These parameters were not statistically different between genders. CONCLUSIONS: Quetiapine was absorbed quickly, distributed widely, and metabolized mainly to be quetiapine sulfoxide. The elimination speeds of quetiapine and its three metabolites were similar. Gender had no effect on the pharmacokinetics of quetiapine and its metabolites. The clinical dosage regime caused no drug accumulation.