Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms

• 来源期刊: 中国药理学报（英文版）
• 关键词: Ganoderma lucidum polysaccharides triterpene immunomodulatory activities anti-tumor activities
• 年，卷（期）: 2004,（11）
• 页码范围: 1387-1395
• 页数: 9页
• 语种: 英文

摘要

Ganoderma lucidum (G lucidum) is a medicinal fungus with a variety of biological activities. It has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its immunomodulatory and anti-tumor activities. Large numbers of studies have shown that G lucidum modulate many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes. The water extract and the polysaccharides fraction of G lucidum exhibited significant anti-tumor effect in several tumor-bearing animals mainly through its immunoenhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of G lucidum possessed antitumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum.