Extensive Studies on the AIEt3/THF-Promoted Diastereoselective Tandem Rearrangement/Reduction of α-Hydroxy (Amino) Heterocyclopropane: An Efficient Approach to 2-Quaternary 1,3-Diheteroatom Units

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2004,（10）
• 页码范围: 1177-1182
• 页数: 6页
• 语种: 英文

摘要

A facile and highly diastereoselective method for the construction of 2-quaternary 1,3-amino alcohols and 1,3-diols has been developed on the basis of the A1Et3/THF-promoted tandem rearrangement/reductive reaction of α-hydroxy (amino) aziridines (epoxides). The progressive achievement in this article included that both 2-epimers of the units could be constructed from the initially same substrate. Also a stereochemistry assignment we reported previously was corrected.