Perfect high throughput screening assay: a crucial technique for drug discovery

• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2005,（10）
• 页码范围: 1174
• 页数: 1页
• 语种: 英文

摘要

Since being developed approximately 20 years ago, high throughput screening (HTS) has become one of the key techniques used in drug discovery[1]. However, three main problems are recognized with the use of HTS; namely, with the compound library, drug targets, and assay methods. Until now, the compound library has evolved based on the techniques of combinatorial chemistry and modern phytochemistry. Several functional proteins have emerged following the advance of genomics and proteomics. However,although many functional proteins have been discovered recently, they are not, as sometimes claimed, real drug targets;at best, they might be potential drug targets. The ideal targets selected for drug screening should qualify as drug targets[2]. The selection of targets for drug screening is a crucial procedure in drug screening.