Using recombinant CD74 protein to inhibit the activity of macrophage migration inhibitory factor （MIF） in vitro

• 作者: Zhi-xinSHAN Xi-yongYU Qiu-xiongLIN Yong-hengFU
• 来源期刊: 中国药理通讯
• 学科: 医学
• 关键词: 组织器官 CD74蛋白 抑制作用 巨噬细胞 细胞移植 抑制因子 MIF 动脉粥样硬化
• 年，卷（期）: zgyltx,（2）
• 页码范围: 28-29
• 页数: 2页
• 分类号: R541.4

摘要

AIM Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in the pathogenesis of a variety of autoimmune and inflammatory diseases, including arthritis, glomerulonephritis, Gram-positive and Gram-negative sepsis, and atherogenesis. Recent studies showed that CD74(antigen-associated invariant chain Ⅱ) is a high-affinity membrane-binding protein for MIF. The purpose of the present study was to express the recombinant human CD74 in E. coli and inhibit the activity of MIF by using recombinant CD74 in vitro.