Effects of OATP -C gene polymorphisms and low-dose rifampicin on serum bilirubin level

• 作者: WeiZHANG Yi-jingHE QingLI Hong-haoZHOU
• 来源期刊: 中国药理通讯
• 学科: 医学
• 关键词: OATP-C基因 基因多态性 少量 利福平 免疫血清 胆红素 聚合酶
• 年，卷（期）: 2005,（2）
• 页码范围: 35-36
• 页数: 2页
• 分类号: R394

摘要

AIM OATP-C is a liver-specific organic anion uptake transporter and shows high affinity for bilirubin uptaking. Rifampicin has been identified as a potent inhibitor of OATP-C both in vitro and in vivo. This study was set to determine the allele frequencies of OATP-C*1a', OATP-C*1b, and OATP-C* 15 in Chinese population, and secondly, to quantitate the contribution of the OATP-C gene polymorphisms and low-dose rifampicin adminstration to the serum bilirubin level in vivo. METHODS Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and a novel tetreprimers method were used to identify OATP-C*1a, OATP-C*1b, and OATP-C*15 genotypes.