Recombinant bispecific antibodies for cancer therapy

• 来源期刊: 中国药理学报（英文版）
• 关键词: antibody engineering bispecific antibody diabodies single-chain diabodies tandemscFv targeting effector cells cancer therapy
• 年，卷（期）: 2005,（1）
• 页码范围: 1-9
• 页数: 9页
• 语种: 英文

摘要

Bispecific antibodies can serve as mediators to retarget effector mechanisms to disease-associated sites. Studies over the past two decades have revealed the potentials but also the limitations of conventional bispecific antibodies. The development of recombinant antibody formats has opened up the possibility of generating bispecific molecules with improved properties. This review summarizes recent developments in the field of recombinant bispecific antibodies and discusses further requirements for clinical development.