Two ligands for a GPCR, proton vs lysolipid

• 来源期刊: 中国药理学报(英文版)
• 关键词: lysolipid proton G-protein-coupled receptor sphingosylphosphorylcholine lysophosphatidylcholine psychosine
• 年，卷（期）: 2005,（12）
• 页码范围: 1435-1441
• 页数: 7页
• 语种: 英文

摘要

Recently, two different chemicals have been matched as ligands with the same Gprotein-coupled receptor (GPCR). Double-pairing of OGR1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs.In this review, I'd like to summarize the issue and discuss questions with pharmacological criteria.