Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats

• 来源期刊: 中国药理学报（英文版）
• 关键词: daidzein daidzein-7- O- glucuronide influence dosage forms pharmacokinetics rats
• 年，卷（期）: 2005,（9）
• 页码范围: 1145-1152
• 页数: 8页
• 语种: 英文

摘要

Aim: To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats. Methods:After administration of two typical dosage forms (daidzein solution and suspension), the concentrations of daidzein and daidzein-7-O-glucuronide were determined by an LC-MS-MS method. The pharmacokinetic parameters were calculated and analyzed statistically using the Student's t-test. Results: Absorption of daidzein after administration of daidzein solution (truax=0.46 h) was more rapid than that of the suspension (tmax=5.00 h). The peak plasma concentrations of daidzein after administration of daidzein solution and suspension were 601.1 μg/L and 127.3 μg/L, respectively, and those of daidzein-7-O-glucuronide were 3000 μg/L and 192.6 μg/L, respectively. The absolute bioavailabilities of free daidzein in rats after administration of daidzein solution and suspension were 12.8% and 6.1%, respectively, which were calculated to be 47.0% and 12.2%, respectively, in the form of total daidzein (free plus conjugated daidzein). Conclusion: Absorption of daidzein solution was better than absorption of suspension (P＜0.05).