复杂性区域疼痛综合症(Complex Regional Paln Syndrome,GRPS)是一种传统治疗方法难以毒效的慢性严重疼痛。Harbut and Correll等人【GE Gorrell,J Malekl.EJ Gracely,JJ Muir, and RE Harbut.Subanesthetic ketamlne Infusion therapy:a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.Paln Med.2004;5(3):263—75】尝试输注小剂量氮胺酮进行治疗。