Molecular mechanisms regulating expression and function of transcription regulator "inhibitor of differentiation 3"

• 来源期刊: 中国药理学报(英文版)
• 关键词: gene expression regulation inhibitor of differentiation 3 protein transcription factors neoplasm
• 年，卷（期）: 2005,（12）
• 页码范围: 1409-1420
• 页数: 12页
• 语种: 英文

摘要

The transcription factor antagonist inhibitor of differentiation 3 (Id3) has been implicated in many diverse developmental, physiological and pathophysiological processes. Its expression and function is subjected to many levels of complex regulation. This review summarizes the current understanding of these mechanisms and describes how they might be related to the diverse functions that have been attributed to the Id3 protein. Detailed understanding of these mechanisms should provide insights towards the development of therapeutic approaches to various diseases, including cancer and atherogenesis.