Phase Ⅱ metabolites of etofesalamide in filamentous fungi1

• 来源期刊: 中国药理学报（英文版）
• 关键词: etofesalamide Cunninghamella metabolite transformation mass spectrum analysis
• 年，卷（期）: 2005,（7）
• 页码范围: 893-896
• 页数: 4页
• 语种: 英文

摘要

Aim: To study phase Ⅱ metabolites of etofesalamide in filamentous fungi.Methods:Seven fungi were screened to transform etofesalamide.The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry.The major metabolite was subject to enzymatic hydrolysis to confirm its structure.Results: Etofesalamide was converted into two phase Ⅱ metabolites: glucoside and riboside conjugates.Glucoside conjugate was the major product with a yield greater than 90%; no phase Ⅰ metabolites were detected.Conclusion: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase Ⅱ metabolism of glucuronidation in mammals.