Structural and magnetotransport properties of Fe-doped Nd0.5 Pb0.5-x Srx MnO3 are investigated by means of x-ray diffraction (XRD), Mossbauer spectroscopy and transport measurements. Both XRD patterns and Mossbauer spectra indicate that structural distortion decreases with Sr doping. Furthermore, it is found that Sr doping results in decrease of the resistivity at room temperature and increase of magnetoresistance. In samples, the same ratio of Mn3+ to Mn4+is kept. So we would rather attribute these changes to the local structural distortion than the double exchange (DE)interaction. The local structural distortion of the Mn(Fe)O6 octahedron which results from the Jahn-Teller effect, can localize the conduction electrons. In this regard, we provide another evidence to prove that this Jahn-Teller distortion is an important factor that affects the transport property above Tc besides the DE coupling.