Hemicentins are conserved extracellular matrix proteins discovered in Caenorhabditis elegans,with orthologs inall vertebrate species including human and mouse.Hemicentins share a single,highly conserved amino-terminal vonWillebrand A domain,followed by a long(>40)stretch of immunoglobulin repeats,multiple tandem epidermal growthfactors and a fibulin-like carboxy-terminal module.C.elegans has a single hemicentin gene that has pleiotropic functionsin transient cell contacts that are required for cell migr...