A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindolines via AIEt3-promoted Tandem Reductive Rearrangement of α-Hydroxy Epoxides

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2006,（5）
• 页码范围: 595-597
• 页数: 3页
• 语种: 英文

摘要

The fully substituted cyclopentenedione core of madindoline A (1) and B (2) as potent and selective inhibitor of IL-6 has been synthesized efficiently. The quaternary carbon center C-2′ was constructed on the basis of a newly developed AIEt3-promoted tandem reductive rearrangement of α-hydroxy epoxides.