New bioactive constituents from eleutherine americana

• 来源期刊: 中国高等学校学术文摘·化学
• 关键词: Eleutherine americana bioactivity Pyricularia oryzea human erythroleukemia
• 年，卷（期）: 2006,（3）
• 页码范围: 320-323
• 页数: 4页
• 语种: 英文

摘要

Three new constituents were isolated from Eleutherine americana Merr.et K.Heyne (hong-cong) by means of silica gel,octadecyl silane (ODS) column chromatography and high-performance liquid chromatography (HPLC).They were identified as (1) 9,9'-dihydroxy-8,8'-dimethoxy- 1 '-dimethyl- 1H,1H'- [4,4']bis[naphtha[2,3-c]funanyl]-3,3'-dione; (2) 6,8-dihydroxy-3,4-dimethoxy- 1 -methyl-anthraquin-one-2-carboxylic acid methyl ester; and (3)2-acetyl-3,6,8-trihydroxy-l-methyl anthraquinone by the physico-chemical properties and spectral data,respectively.All three compounds showed weak activities against the growth of Pyricularia oryzea.The minimum morphological deformation concentration (MMDC) was 145.8,50.2,and 124.8 μg/mL.Additionally,(2) also inhibited the proliferation of human erythroleukemia cancer cell line K562 with IC50 value of 49.1 μg/mL.