Biocatalytic Synthesis of Highly Enantiopure 1,4-Benzodioxane-2-carboxylic Acid and Amide

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2006,（11）
• 页码范围: 1665-1668
• 页数: 4页
• 语种: 英文

摘要

Catalyzed by Rhodococcus erythropolis A J270, a nitrile hydratase and amidase containing microbial whole-cell catalyst, at 10 ℃ and with the use of methanol as a co-solvent, nitrile and amide biotransformations produce 2S-1,4-benzodioxane-2-carboxamide and 2R-1,4-benzodioxane-2-carboxylic acid in high yields with excellent enantioselectivity.