Spectroscopic Study on Interaction of β-Cyclodextrin with Triprolidine Hydrochloride

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2006,（5）
• 页码范围: 665-668
• 页数: 4页
• 语种: 英文

摘要

The complexation of triprolidine hydrochloride (TRP) and β-cyclodextrin (β-CD) in deuterium oxide was investigated by 400 MHz 1H NMR spectroscopy. The 800 MHz 2D ROESY data reveaed that two 1 : 1 and one 2: 1β-CD-TRP inclusion complexes were formed. Both aromatic moieties (p-tolyl and pyridyl ring) has entered into the β-CD cavity, confirming the existence of two different equilibria for 1: 1 inclusion complexes in which p-tolyl ring of the guest is more tightly held by the host cavity. The ROE intermolecular interactions provided the plausible structures of these 1: 1 and 2: 1 stoichiometric inclusion complexes of β-CD-triprolidine hydrochloride in solution.