Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Chiral Amino Alcohols

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2006,（10）
• 页码范围: 1285-1289
• 页数: 5页
• 语种: 英文

摘要

(S)-(1-Benzylpyrrolidin-2-yl)diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones, in order to prepare chiral propargylic alcohols. Good yields (up to 89%) and moderate enantioselectivities (up to 77.9% ee) were achieved. Addition of Ti(OPr-i)4 can significantly improve the enantioselectivity of the reaction.