STAT3 as a target for inducing apoptosis in solid and hematological tumors

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2008,（2）
• 页码范围: 254-267
• 页数: 14页
• 语种: 英文

摘要

Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented.