Synthesis of 3-O-methyI-D-chiro-inositol adenosine analogues

• 来源期刊: 中国高等学校学术文摘·化学
• 关键词: 3-O-methyl-D-chiro-inositol carbocyclic nucleoside analogues adenine regioselectivity
• 年，卷（期）: 2008,（4）
• 页码范围: 464-466
• 页数: 3页
• 语种: 英文
• DOI: 10.1007/s11458-008-0071-7

摘要

Using 3-O-methyl-D-chiro-inositol as starting material, the title compound 5 was synthesized by con-densation of adenine and methanesulfonate 3. Additionally, compounds 8 and 9 were prepared through the opening of the epoxide ring in 7 by adenine. The key intermediate 7 was obtained in good yield via an epoxida-tion from mono-mesylate 6. The process of opening of epoxide ring appeared to be regioselective in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).