Mechanisms of p53-mediated mitochondrial membrane permeabilization

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2008,（7）
• 页码范围: 708-710
• 页数: 3页
• 语种: 英文

摘要

The p53 protein is mutated or inactivated in more than 50% of human cancers, underscoring its cardinal importance as an oncosuppressor, p53 is expressed in all nucleated cells and can be activated by a plethora of post-transcriptional modifications (in particular by the phosphorylation of critical serine residues), as well as by the inhibition of its degradation (mainly mediated by the E3 ubiquitin ligase MDM2).