The aryl hydrocarbon receptor:a regulator of Th17 and Treg cell development in disease

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2008,（6）
• 页码范围: 605-608
• 页数: 4页
• 语种: 英文

摘要

The aryl hydrocarbon receptor (AhR)was discovered almost 30 years ago as a specific binding site for the halogenated polycyclic aromatic hydrocarbon,2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD),an environmental toxin (as reviewed in [1]).Within the last decade,AhR was found to have a basic helixloop-helix and function as a ligand-activated transcription factor.Located in the cytoplasm of most cells,AhR forms a receptor complex with several proteins including the chaperone protein hsp90 (a 90kDa heat shock protein).