Knockdown of flotillin-2 inhibits lung surfactant secretion by alveolar type Ⅱ cells

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2008,（6）
• 页码范围: 701-703
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, Lung surfactant is stored in lamellar bodies and exocytosed following fusion of the lamellar bodies with the plasma membrane of alveolar type Ⅱ (AT2) cells [1].A number of proteins have been shown to be involved in surfactant secretion including SNAREs,NSF,α-SNAP and annexin A2 [2,3].Lipid rafts enriched in SNAREs are crucial for surfactant secretion [4].