Paneth cells and inflammation dance together in Crohn's disease

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2008,（12）
• 页码范围: 1160-1162
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2008.312

摘要

Inflammatory Bowel Disease (IBD)is a dysregulated response of the immune system associated with intestinal tissues to the commensal microbiota in a genetically susceptible host.The understanding of the genetic basis of IBD has been significantly expanded with the advent of genome-wide association studies (GWAS) which has resulted in the identification of more than 30 loci that are associated with Crohn's disease(CD) and ulcerative colitis (UC).