Design of artificial nucleases and studies of their interaction with DNA

• 来源期刊: 中国科学B辑（英文版）
• 年，卷（期）: 2009,（4）
• 页码范围: 402-414
• 页数: 13页
• 语种: 英文
• DOI: 10.1007/s11426-009-0029-8

摘要

The design of artificial nucleases and nuclease mimics has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of gene medicine and molecular biology. This paper reviews recent progress in the investigation of artificial nuclease, including "bifunctional cooperative catalysis", "dinuclear synergistic catalysis", "metal-free catalysis", and especially, the studies of aza-crown ethers as artificial nucleases and their interaction with DNA.