Synthesis of an AlE-active fluorogen and its application in cell imaging

• 来源期刊: 中国科学B辑(英文版)
• 年，卷（期）: 2009,（1）
• 页码范围: 15-19
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11426-009-0008-0

摘要

A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (ALE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor.