Self-assembling bacterial pores as components of nanobiosensors for the detection of single peptide molecules

• 来源期刊: 中国科学B辑（英文版）
• 年，卷（期）: 2009,（6）
• 页码范围: 731-733
• 页数: 3页
• 语种: 英文
• DOI: 10.1007/s11426-009-0078-z

摘要

Nano-sized bacterial pores were inserted into a lipid membrane as a nanobiosensor for the detection of single peptide molecules. Due to the intrinsic properties of single-channel conductance, the transit of individual molecules through the pore can be studied. The analysis of both the blockage current and duration is able to provide specific structural information and allows the detection of specific peptides in bulk mixtures.