Investigations of the interaction between cuprous oxide nanoparticles and Staphylococcus aureus

• 来源期刊: 中国科学B辑(英文版)
• 年，卷（期）: 2009,（7）
• 页码范围: 1028-1032
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11426-009-0004-4

摘要

Cuprous oxide nanoparticles of 30-50 nm in size were prepared in the presence of cetyltrimethylammonium bromide (CTAB).By taking Staphylococcus aureus (S.a),which always causes a variety of suppurative infections and toxinoses in humans,as a model bioparticle,the negative bioeffect of nano-Cu2O on S.a cells was evaluated,and minimal inhibitory concentration (MIC) was determined by imitating the MIC of antibiotics.Cellularity and bactericidal effect were measured by flow cytometry (FCM),dark field light scattering imaging and SEM photography.The results showed that nano-Cu2O particles may,by absorbing on the cell surface,impair the cell wall,damage the cell membrane,and finally increase permeability of the cell membrane,thus leading to a decrease in the viability of bacteria in the nano-Cu2O solution.