Based on the virial theory, we proposed VLW equation of state of detonation products (VLW EOS). Its basic theory and applications were described. The distinct features of the VLW EOS were: First, the detonation performance of the new high energy density materials could be predicted more reliably. Second, it had extensive application. The detonation parameters of both the condensed high energy density materials and the gaseous fuel air explosives could be calculated. Moreover, combustion per-formance of propellants could also be precisely calculated. The calculation results were satisfactory.