The molecular mechanism of photodynamic therapy to fibrosis: Regulation on the pyridinoline cross-link formation in collagen

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2009,（13）
• 页码范围: 2230-2234
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11434-009-0420-z

摘要

Fibrotic processes in tissues are characterised by an excessive accumulation of collagen containing increased levels of pyridinoline cross-links,which has been taken as an important criterion to diagnose the fibrosis.Hypocrellin B (HB) is a natural photosensitizer with excellent photodynamic activity but very low dark-toxicity.In the current work,main purpose was to clarify if photodynamic action of HB could be applied to regulating the level of pyridinoline cross-link in collagen.To use gelatin as a model collagen,it was observed that the pyridinoline cross-link formation was effectively degraded by HB photodynamic action in the gelatin,suggesting the level of pyridinoline cross-link formation in collagen may be photodynamically regulated to a normal level.Furthermore,mechanism of the photodynamic action of HB was studied.