Role of post-translational modifications of HTLV-1 Tax in NF-κB activation

• 作者: Edward W Harhaj Noula Shembade
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Adult-T-cell leukemia/lymphoma HUMAN T-CELL LEUKEMIA VIRUS TYPE 1 Nuclear factor-κB HUMAN T-CELL LEUKEMIA VIRUS TYPE 1-associated myelopathy/ tropical spastic PARAPARESIS IKK
• 年，卷（期）: 2010,（1）
• 页码范围: 13-20
• 页数: 8页
• 分类号: R733.7

摘要

Human T-cell leukemia virus type 1(HTLV-1),the first human retrovirus discovered,is the etiological agent of adult-T-cell leukemia/lymphoma.The HTLV-1 encoded Tax protein is a potent oncoprotein that deregulates gene expression by constitutively activating nuclear factor-κB(NF-κB).Tax activation of NF-κB is critical for the immortalization and survival of HTLV-1-infected T cells.In this review,we summarize the present knowledge on mechanisms underlying Tax-mediated NF-κB activation,with an emphasis on post-translational modifications of Tax.