Separation Anxiety: Detachment from the Extracellular Matrix Induces Metabolic Changes that Can Stimulate Tumorigenesis

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2010,（3）
• 页码范围: 113-115
• 页数: 3页
• 语种: 英文

摘要

One of the earliest stages of tumor progression involves the ability of cells to survive and proliferate when not attached to the extracellular matrix (ECM). New research using a physiologically relevant breast cancer model reveals how separation from the ECM stimulates metabolic changes characteristic of developing tumors.