Diverticular disease: A therapeutic overview

• 作者: Antonio Tursi
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: DIVERTICULITIS ANTIBIOTICS 5-Aminosalicylic acid MESALAZINE PROBIOTICS
• 年，卷（期）: sjwcylyzlxzzywbdzb_2010,（1）
• 页码范围: 27-35
• 页数: 9页
• 分类号: R574

摘要

Formation of colonic diverticula, via herniation of the colonic wall, is responsible for the development of diverticulosis. When diverticulosis becomes symptomatic, it becomes diverticular disease. Diverticular disease is common in Western and industrialized countries, and it is associated with numerous abdominal symptoms (including pain, bloating, nausea, diarrhea, and constipation). Standard medical therapies with antibiotics are currently recommended for patients affected by diverticular disease. However, changing concepts on the pathophysiology of the disease suggest that diverticular disease may share many of the hallmarks of inflammatory bowel diseases. On this basis, the addition of therapies using mesalazine and probiotics may enhance treatment eff icacy by shortening the course of the disease and preventing recurrences.