Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism

• 作者: Michiaki Yamashita Takeshi Yabu Yumiko Yamashita
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Selenium-containing compound ANTIOXIDANT METHYLMERCURY Organic cations/carnitine transporter OCTN1 ERGOTHIONEINE Glutathione peroxidase TUNA Fish
• 年，卷（期）: 2010,（5）
• 页码范围: 144-150
• 页数: 7页
• 分类号: R151

摘要

A novel selenium-containing compound,selenoneine,has been isolated as the major form of organic selenium in the blood and tissues of tuna.Selenoneine harbors a selenium atom in the imidazole ring,2-selenylNα,Nα,Nα-trimethyl-L-histidine,and is a selenium analog of ergothioneine.This selenium compound has strong antioxidant capacity and binds to heme proteins,such as hemoglobin and myoglobin,to protect them from iron auto-oxidation,and it reacts with radicals and methylmercury(MeHg) .The organic cations/carnitine transporter OCTN1 transports selenoneine and MeHg,regulates Se-enhanced antioxidant activity,and decreases MeHg toxicity.Thus,the dietary intake of selenoneine,by consuming fish,might decrease the formation of reactive oxygen radicals that could oxidize nucleotides in DNA,and thereby inhibit carcinogenesis,chronic diseases,and aging.