As requested by many participants,I would like to share with you the opening remark,which I made at the Third Asia-Pacific Forum on Androiogy,in conjunction with the Celebration of the Tenth Anniversary of Asian Journal of Andrology,Nanjing,China,October 10,2009. In my opening remark,I raised three questions about the development of Andrology,as well as highlighted three major trends of current progress of life science,which might be of great help in setting up our strategy for Andrology development in the coming years.