Janus Kinase 2: An Epigenetic 'Writer' that Activates Leukemogenic Genes

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2010,（5）
• 页码范围: 231-233
• 页数: 3页
• 语种: 中文
• DOI: 10.1093/jmcb/mjp054

摘要

Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes Hplalpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1α from chromatin through phosphorylation of histone H3.