Mesalamine induced symptom exacerbation of ulcerative colitis: Case report and brief discussion

• 作者: John J Hutchings Maneesh Kumar Gupta Scott Pollack
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: MESALAMINE EXACERBATION ULCERATIVE coli-tis Inflammation ADVERSE drug reaction
• 年，卷（期）: 2010,（6）
• 页码范围: 132-134
• 页数: 3页
• 分类号: R574.62

摘要

This paper describes a rare case in which the oral ad-ministration of mesalamine resulted in the exacerbation of ulcerative colitis (UC) in a patient who was previously responsive to mesalamine and whose colitis had been in remission for eight years. Mesalamine and other 5-ami-nosalicylic acid compounds are the mainstay of treatment for UC; however up to 8% of patients are unable to take the medications due to intolerance or hypersensitivity reactions. Common drug reactions are fever, nausea, di-arrhea and abdominal pain; however, exacerbation of UC has rarely been reported. This study highlights the impor-tance of ruling out mesalamine as the causative agent in cases of UC exacerbations.