For cancers there is more to life than a longer G-strand

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2010,（6）
• 页码范围: 779-782
• 页数: 4页
• 语种: 英文
• DOI: 10.1038/aja.2010.103

摘要

Three recent studies from the Wright [1], Chai [2] and de Lange [3] labs have elucidated previously neglected aspects of cancer cell telomere maintenance. Because inhibiting telomere maintenance can selectively kill cancer ceils without harming normal cells [4, 5], this new understanding of the mechanism and dynamics involved may provide useful new strategies for treating cancer. Until recently,research had focused on how cancer cells elongate the telomeric G-strand. However, during every cell division the telomeric C-strand also needs to be elongated and the appropriate end-structure recreated to maintain telomere length and function.