Tom70 imports antiviral immunity to the mitochondria

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2010,（9）
• 页码范围: 971-973
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2010.113

摘要

RLRs - the retinoic acid-inducible gene-Ⅰ (RIG-Ⅱ) and melanoma differen-tiation-associated gene 5 (MDA5) - are novel cytoplasmic RNA helicases that recognize viral RNA present within the cytoplasm [1]. The identification of the MAVS (mitochondrial antiviral signal-ing) adaptor protein as a member of the RIG-Ⅰ-like receptors (RLRs) signaling pathway links the mitochondria to the mammalian antiviral defense system [2]. MAVS contains an amino-terminal CARD that interacts with the CARD domains of RIG-Ⅰ/Mda5 and a carboxyl-terminal transmembrane domain that targets MAVS to the outer mitochon-dria. The localization of MAVS acta as a pivotal scaffold for triggering the antiviral cascade via activation of the transcription factors NF-κB, IRF3 and IRF7 (Figure 1).