有与 sorafenib 对待的严重的肝机能障碍的 HCC 病人的长期的幸存

• 作者: Andreas Mahnken Christian Trautwein Christoph Roderburg Jens JW Tischendorf Jhenee Bubenzer Michael Spannbauer Nicole do O Tom Luedde
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HEPATOCELLULAR carcinoma SORAFENIB Liver CIRRHOSIS CHILD-PUGH SCORE Long-term survival
• 年，卷（期）: 2010,（6）
• 页码范围: 239-242
• 页数: 4页
• 分类号: R735.7

摘要

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Prognosis and treatment options are stage dependent. In general, prognosis of patients with unresectable HCC is poor, especially for those patients with impaired liver function. Whereas treatment with the novel molecular tyrosine kinase inhibitor sorafenib (Nexavar) was shown to result in prolonged survival in patients with preserved liver function, its’ possible application in HCC-patients with strongly impaired liver function has not been clearly assessed. Here, we report on a 47-year-old male patient who presented with Child-Pugh class C liver cirrhosis and multifocal, non-resectable HCC. The patient was treated for 27 mo with Sorafenib, which was not associated with major drug-related side effects. During treatment, a reduction in tumour size of 24% was achieved, as assessed by regular CT scan. Moreover,within the 27 mo interval of stable tumour disease, liver function improved from Child-Pugh class C to class A.