Hematopoietic stem and progenitor cells in HIV/AIDS and immune reconstitution

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2010,（7）
• 页码范围: 745-747
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2010.85

摘要

The human immunodeficiency virus type 1 (HIV-1) causes an acquired immunodeficiency syndrome (AIDS).HIV-1 infects human immune cells,specifically CD4+ lymphocytes, which leads to AIDS and undermines reconstitution of immunity. The unique challenges of HIV/AIDS have triggered multidisciplinary investigators to study the virology of the pathogen and the biology of the host cells, especially the interactions of HIV-1 with T-lymphocytes,macrophages, and hematopoietic stem and progenitor cells (HSPC) [1-8].