Enantioselective direct aldol-type reaction of 4-hydroxycoumarin with ethyl trifluoropyruvate catalyzed by modified cinchona alkaloids

• 来源期刊: 科学通报(英文版)
• 学科: 工学
• 关键词: 对映选择性 三氟甲基 金鸡纳生物碱 反应 羟基 改性 催化 乙基
• 年，卷（期）: 2010,（17）
• 所属期刊栏目: LETTERS
• 页码范围: 1732-1734
• 页数: 3页
• 分类号: TQ463.4 O626
• 语种: 英文

摘要

A new enantioselective aldol-type reaction of 4-hydroxycoumarins and ethyl trifluoropyruvate has been developed. In the presence of (DHQD)2PHAL (5 mol%), ethyl trifluoropyruvate could react with various 4-hydroxycoumarins to afford novel 4-hydroxycoumarin derivatives containing a tertiary trifluoromethyl alcohol center in good yields with moderate enantioselectivities.