Cytoplasmic Ca2+ Dynamics under the Interplay between the Different IP3R Gating Models and the Plasma Membrane Ca2+ Influx

• 作者: 李丛鑫 王渭池 王鹏业 陈晓芳
• 来源期刊: 中国物理快报(英文版)
• 学科: 生物学
• 关键词: 细胞质膜 胞质钙 相互作用 模型 浇注 动力学 调制方式 振幅变化
• 年，卷（期）: 2010,（1）
• 页码范围: 60-63
• 页数: 4页
• 分类号: Q942.5 Q942.6
• 语种: 英文

摘要

The cytoplasmic Ca2+ oscillations are investigated under the effect of CRAC channels in non-excitable cells (especially in T cells). The oscillatory Ca2+ signals can be modulated as the amplitude-, frequency- and mixed amplitude-frequency modulation modes dependent on the different IP3R gating models. Bifurcation analyses show that Ca2+ signals in the single positive feedback loop model is a mixed modulation mode. In contrast, Ca2+ signals in the Mak-McBride-Foskett model demonstrates approximately the frequency modulation mode only with slight amplitude shifts.