Identifying changed protein-protein interactions in biological processes by gene coexpression analysis

• 来源期刊: 科学通报(英文版)
• 学科: 生物学
• 关键词: 蛋白质相互作用 相互作用力 生物过程 表达分析 基因 识别 价格指数 转化生长因子
• 年，卷（期）: 2010,（14）
• 页码范围: 1396-1402
• 页数: 7页
• 分类号: Q51 O441
• 语种: 英文

摘要

The interaction strength between 2 proteins is not constant but variable under different conditions. For a given biological process, identification of protein-protein interactions (PPIs) undergoing dynamic change in interaction strength is highly valuable but never achieved before. In this work, we presented a computational approach to identify changed PPIs (cPPIs) on a global scale by analyzing the coexpression level of genes encoding the interacting protein pairs. This approach stemmed from the biological...