Stochastic Four-State Mechanochemical Model of F1-ATPase

• 来源期刊: 理论物理通讯(英文版)
• 学科: 农学
• 关键词: ATP酶 力模型 机械力 随机 浓度依赖性 三磷酸腺苷酶 旋转速度 ATP分子
• 年，卷（期）: 2010,（10）
• 页码范围: 630-634
• 页数: 5页
• 分类号: S511.01 TS941.562
• 语种: 英文

摘要

F1-ATPase, a part of ATP synthase, can synthesize and hydrolyze ATP moleculars in which the centralγ-subunit rotates inside the α3β3 cylinder.A stochastic four-state mechanochemical coupling model of F1-ATPase isstudied with the aid of the master equation.In this model, the ATP hydrolysis and synthesis are dependent on ATP,ADP, and Pi concentrations.The effects of ATP concentration, ADP concentration, and the external torque on theoccupation probability of binding-state, the rotation rate and the diffusion coefficient of F1-ATPase are investigated.Moreover, the results from this model are compared with experiments.The mechanochemical mechanism F1-ATPase isqualitatively explained by the model.