Preparation of α-Bromoketones and Thiazoles from Ketones with NBS and Thioamides in Ionic Liquids

• 作者: Hideo Togo Yuhta Izumisawa
• 来源期刊: 绿色与可持续化学(英文)
• 学科: 化学
• 关键词: Ketone α-Bromoketone Thiazole NBS THIOAMIDE Ionic Liquid
• 年，卷（期）: 2011,（3）
• 页码范围: 54-62
• 页数: 9页
• 分类号: O6

摘要

Ketones smoothly reacted with NBS in the presence of a catalytic amount of ptoluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids could be repeatedly used for the same reaction after the extraction of the α-bromoketones. Then, the one-pot conversion of ketones into thiazoles by the treatment with NBS, and subsequently with thioamides could be also carried out in [bmim]PF6 and [bmpy]Tf2N, respectively Thus, [bmim]PF6 and [bmpy]Tf2N could be used as recyclable reaction media for the preparation α-bromoketones and thiazoles from ketones.