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Background: A meta-analysis was performed to determine the value of 2-18fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for assessing viable tumor residuals after chemotherapy in patients with pure seminoma. Materials and methods: This review included five studies published between 1999 and 2010 with a total of 130 patients who underwent both computed tomography (CT) and FDG-PET scanning for residual tumor detection after systemic therapy. We compared the sensitivity and specificity of FDG-PET and CT (tumor size ≤ or > 3 cm) in identifying vital tumor tissue. Results: On the average, FDG-PET had higher specificity (92% vs. 59%) and sensitivity (72% vs. 63%) as well as a higher positive predictive value (PPV) than the solely size-based CT assessment of residual tumors (70% vs. 28%). PEt also tended to have a higher negative predictive value (93% vs. 86%). Conclusion: The present evaluation of currently available data indicates that FDG-PET is superior to CT in detecting viable tumor residuals after chemotherapy in patients with metastatic seminoma. Its application can thus be recommended.
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篇名 Meta-Analysis to Determine the Diagnostic Value of 2-<sup>18</sup>Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography in Assessing Residual Tumors after Systemic Therapy for Metastatic Seminoma
来源期刊 泌尿学期刊(英文) 学科 医学
关键词 FDG-PET SEMINOMA TESTICULAR Cancer Diagnosis Residual Disease
年,卷(期) 2011,(3) 所属期刊栏目
研究方向 页码范围 50-55
页数 6页 分类号 R73
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FDG-PET
SEMINOMA
TESTICULAR
Cancer
Diagnosis
Residual
Disease
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泌尿学期刊(英文)
季刊
2160-5440
武汉市江夏区汤逊湖北路38号光谷总部空间
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324
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0
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