Genetically targeting new neurons in the adult hippocampus

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（2）
• 页码范围: 220-222
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2010.148

摘要

Neurogenesis, the birth of new neu-rons from neural stem cells, is known to occur throughout life in two specific regions of the adult mammalian brain, the subgranular zone/hippocampal dentate gyms and the subventricular zone/olfactory bulb [1-3]. Adult neuro-genesis is a multi-step process (Figure 1), which includes proliferation and fate specification of adult neural stem cells, morphogenesis, migration, axonal and dendritic development, survival, and synaptic integration by newborn neurons [4].