Different developmental potential of pluripotent stem cells generated by different reprogramming strategies

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2011,（3）
• 页码范围: 197-199
• 页数: 3页
• 语种: 中文
• DOI: 10.1093/jmcb/mjr012

摘要

Dear Editor, Recent studies show that induced pluripotent stem cells (iPSCs) generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells (Kim et al., 2010; Polo et al., 2010) or aberrant silencing of a single imprinted gene cluster (Liu et al.,2010; Stadtfeld et al., 2010), which affects their developmental and differentiation potentials.In contrast, nuclear transfer can more faithfully reprogramme somatic cells into embryonic stem (ES)cells (nuclear transfer ES cells, ntESCs)(Brambrink et al., 2006; Wakayama et al.,2006).